Oral Nifedipine versus Intravenous Labetalol for Acute Blood Pressure Control in Severe Hypertension of Pregnancy: A Study at Faridpur Medical College Hospital

The first line antihypertensive treatment for severe hypertension of pregnancy includes labetalol, hydralazine, or nifedipine. Rapid but safe blood pressure control allows the definitive treatment, delivery baby to be carried out with minimal delay and good maternal fetal outcomes. This non-randomized clinical trial was performed in Faridpur Medical College Hospital compare effectiveness tolerability oral nifedipine intravenous labetalol acute pregnancy. Total 50 admitted pregnant women a viable fetus (>_ 24 weeks gestation) having were allocated into two groups, Group A: 25 patients receiving (10 mg), B: injectable (with incremental doses: 20, 40, 80mg). Up 5 doses tried each drug at 15 minutes interval until target (<_150/100 mmHg) achieved. Baseline characteristics like mean age, weight, heart rate, systolic diastolic pressures similar both groups. average time required achieve 30.33 ± 10.44 25.63 10.12 (p=0.9129). Feto-maternal outcomes adverse related effects among Both found equally effective well tolerated. Nifedipine may preferable as it is simple, flat dose schedule an regimen.
 Med. Coll. J. 2021;16(1):25-29